Supplement–drug interactions
Supplements That Interact with Sedatives (benzodiazepines, opioids, alcohol)
11 supplements in NutriDex have a known or theoretical interaction with sedatives (benzodiazepines, opioids, alcohol), including 3 best avoided entirely. Grouped by severity below; each links to its full evidence, dosing & mechanism. This is educational and not exhaustive — always tell your doctor or pharmacist about every supplement you take before combining it with medication.
Avoid — do not combine 3
Caution — use only with medical guidance 3
Can add to drowsiness and sedation, increasing grogginess and impaired alertness.
Additive drowsiness and sedation; can slow the nervous system too much, impairing alertness and coordination.
Additive drowsiness and sedation; can impair alertness and raise fall/accident risk.
Monitor — watch for effects 5
May add to drowsiness and sedation when combined with CNS depressants.
May add to drowsiness; theoretical additive sedation when combined with sedative medicines.
May add to drowsiness and sedation when combined with sleep medicines, benzodiazepines or alcohol.
May add to drowsiness; theoretical additive sedation with sedative drugs, important before surgery/anesthesia.
May add to drowsiness and sedation when taken with sleep medicines, benzodiazepines or alcohol.
Each supplement links to its full evidence, dosing, mechanism & citations. See also all medication interaction guides →