Supplement–drug interactions
Supplements That Interact with CYP3A4 drugs (some statins, CCBs, immunosuppressants)
5 supplements in NutriDex have a known or theoretical interaction with cyp3a4 drugs (some statins, ccbs, immunosuppressants), including 1 best avoided entirely. Grouped by severity below; each links to its full evidence, dosing & mechanism. This is educational and not exhaustive — always tell your doctor or pharmacist about every supplement you take before combining it with medication.
Avoid — do not combine 1
Grapefruit can sharply raise levels of simvastatin/atorvastatin and other CYP3A4 drugs — toxicity risk.
Caution — use only with medical guidance 2
Pomelo, a grapefruit relative, can similarly raise levels of CYP3A4 drugs; treat like grapefruit.
Can reduce blood levels and effectiveness of a wide range of CYP3A4-metabolized medicines.
Monitor — watch for effects 2
As a citrus product, bergamot may mildly affect CYP3A4-metabolized drug levels; monitor for side effects.
May alter blood levels of CYP3A4/P-gp drugs such as cyclosporine; monitor levels and effects.
Each supplement links to its full evidence, dosing, mechanism & citations. See also all medication interaction guides →