NutriDex

The Supplement Research Compendium

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Sweet Cherry

Prunus avium

Anthocyanin-rich stone fruit with cardiometabolic promise

Moderate evidence 🍎Fruits
Evidence tier
Moderate
Research weight
Citations
8 verified / 8
Classification
Fruits
What the evidence says. Several controlled trials; effects real but modest or context-dependent.

Nutrition per serving 1 cup pitted (138 g)

138gSERVING
  • Water 113.4 g83%
  • Sugars 17.7 g13%
  • Fibre 2.9 g2%
  • Other carbs 1.5 g1%
  • Protein 1.5 g1%
  • Fat 0.3 g0%
What's in one serving, by weight — average composition (USDA).
Potassium7%Vitamin C11%Fiber10%Copper9%Manganese4%Vitamin K2%
One serving as % of the adult daily requirement (FDA Daily Values). The bold outer ring = 100% of a day's needs.
87 kcal1.5 g protein2.9 g fiber0.3 g fat
NutrientPer serving% daily value
Potassium306 mg7%
Vitamin C9.7 mg11%
Fiber2.9 g10%
Copper0.08 mg9%
Manganese0.1 mg4%
Vitamin K2.9 mcg2%
Magnesium15 mg4%
Vitamin A4 mcg RAE0%

Composition data: USDA FoodData Central ↗

What is Sweet Cherry?

Sweet Cherry (Prunus avium) is a fruit used for anti-inflammatory effects (lowers crp, ifn-γ in some trials). NutriDex grades the human evidence as Moderate. Sweet cherries (Prunus avium) are a low-energy, water-rich fruit whose polyphenols—especially anthocyanins and hydroxycinnamic acids—drive most of the studied bioactivity. In a 30-day single-blind randomized placebo-controlled trial in obese adults, a dark sweet cherry drink (200 mL twice daily) modestly lowered systolic and diastolic blood pressure and reduced pro-inflammatory IFN-γ, though a pooled meta-analysis of seven cherry RCTs found no significant overall blood-pressure effect. Observational and small interventional data link cherry intake to lower serum urate and roughly 35% fewer recurrent gout attacks (case-crossover data), but a dedicated meta-analysis was not feasible because of heterogeneity. The best-replicated benefits—accelerated muscle-strength recovery, reduced soreness, and improved sleep via melatonin—come overwhelmingly from tart cherry (Prunus cerasus), so they should not be assumed identical for sweet cherry. Most studies are small, short, and use concentrated juice or powder rather than whole fresh fruit, limiting how far results generalize to ordinary dietary servings. Overall the human evidence is best described as moderate and mechanistically plausible but heterogeneous, with sweet-cherry-specific clinical data still sparse. As a whole food, sweet cherries are a sensible, nutrient-dense choice regardless of the targeted-effect uncertainty.

Purported Benefits

Anti-inflammatory effects (lowers CRP, IFN-γ in some trials)
Modest blood-pressure lowering in obese/at-risk adults (single trial; not confirmed in pooled analysis)
Reduced serum urate and fewer recurrent gout flares (mostly cherry/tart-cherry data)
Faster recovery of muscle strength and less soreness after strenuous exercise (chiefly tart cherry)
Improved sleep duration/quality via melatonin and anthocyanins (chiefly tart cherry)
Antioxidant capacity from polyphenol-rich profile

Dosing & Compounds

Typical Dose
1 cup pitted (about 138 g, ~21 cherries) fresh; many trials use 200-300 mL cherry juice/drink once or twice daily
Active Compounds
Anthocyanins (cyanidin-3-rutinoside, cyanidin-3-glucoside)Hydroxycinnamic acids (neochlorogenic, chlorogenic, p-coumaroylquinic acid)Flavonols (quercetin, kaempferol glycosides)Flavan-3-ols / proanthocyanidins (catechin, epicatechin)MelatoninVitamin C (ascorbic acid)PotassiumDietary fiber (pectin, cellulose)Carotenoids (beta-carotene, lutein/zeaxanthin)

Safety & Cautions

Generally safe as a food. High in fructose and sorbitol, so large amounts can cause bloating, gas, or diarrhea in sensitive people (including those with IBS or fructose malabsorption). Cherry pits/kernels contain amygdalin, which releases cyanide if crushed/chewed in quantity—do not eat the stones. People with latex-fruit or birch-pollen (oral allergy) syndrome may react. Concentrated cherry juice adds appreciable sugar and calories and may affect glycemic control if overconsumed. Theoretical additive effects with urate-lowering or anti-inflammatory regimens; patients on warfarin should keep vitamin K intake consistent (cherries are low but not zero). Educational only — always check with your doctor or pharmacist before combining Sweet Cherry with any medicine.

Key Studies

GRADE systematic review & meta-analysis of RCTs Norouzzadeh 2023 ✓ PubMed
GRADE-assessed dose-response meta-analysis of 21 RCTs: tart cherry reduced serum CRP (moderate certainty) but did not significantly change hs-CRP or IL-6, and had no significant effect on blood pressure.
Systematic review & meta-analysis of RCTs Eslami 2022 ✓ PubMed
Meta-analysis of 7 RCTs (n=201) of sweet and tart cherry: cherry supplementation produced no statistically significant reduction in systolic or diastolic blood pressure.
Systematic review & meta-analysis Hill 2021 ✓ PubMed
Meta-analysis of 14 studies: tart cherry supplementation significantly improved recovery of muscular strength and power and reduced soreness after strenuous exercise.
Systematic review Chen 2019 ✓ Full text
Systematic review of 6 studies: cherry/tart-cherry intake associated with reduced serum uric acid (up to ~19% with juice) and fewer gout flares; data too heterogeneous for meta-analysis.
Randomized placebo-controlled trial Arbizu 2023 ✓ Full text
30-day single-blind RCT in obese adults (n=40): dark sweet cherry (Prunus avium) drink 200 mL twice daily lowered systolic (p=0.05) and diastolic (p=0.04) blood pressure and reduced pro-inflammatory IFN-γ (p=0.001) vs placebo, without affecting lipids, glucose, or liver enzymes.
Randomized placebo-controlled pilot crossover trial Losso 2018 ✓ PubMed
Placebo-controlled crossover pilot in 8 adults >50 y with insomnia: tart cherry juice (240 mL twice daily) increased polysomnography total sleep time by ~84 minutes vs placebo (p=0.018), attributed partly to procyanidin-B2 inhibition of IDO reducing tryptophan degradation.
Randomized double-blind placebo-controlled crossover trial Pigeon 2010 ✓ PubMed
Randomized double-blind placebo-controlled crossover in 15 older adults with chronic insomnia: a tart cherry juice beverage twice daily for 2 weeks significantly improved subjective insomnia severity vs placebo.
Case-crossover study Zhang 2012 ✓ PubMed
Case-crossover study (633 gout patients): cherry intake over 2 days was associated with 35% lower risk of recurrent gout attacks (OR 0.65, 95% CI 0.50-0.85); risk was ~75% lower (OR 0.25) when cherry was combined with allopurinol.

Common questions about Sweet Cherry

What is Sweet Cherry used for?

Sweet Cherry is most often taken for Anti-inflammatory effects (lowers CRP, IFN-γ in some trials), Modest blood-pressure lowering in obese/at-risk adults (single trial; not confirmed in pooled analysis), Reduced serum urate and fewer recurrent gout flares (mostly cherry/tart-cherry data), Faster recovery of muscle strength and less soreness after strenuous exercise (chiefly tart cherry). Anthocyanin-rich stone fruit with cardiometabolic promise

Does Sweet Cherry work — what does the evidence say?

Moderate evidence. Several controlled trials; effects real but modest or context-dependent. Sweet cherries (Prunus avium) are a low-energy, water-rich fruit whose polyphenols—especially anthocyanins and hydroxycinnamic acids—drive most of the studied bioactivity. In a 30-day single-blind randomized placebo-controlled trial in obese adults, a dark sweet cherry drink (200 mL twice daily) modestly lowered systolic and diastolic blood pressure and reduced pro-inflammatory IFN-γ, though a pooled meta-analysis of seven cherry RCTs found no significant overall blood-pressure effect. Observational and small interventional data link cherry intake to lower serum urate and roughly 35% fewer recurrent gout attacks (case-crossover data), but a dedicated meta-analysis was not feasible because of heterogeneity. The best-replicated benefits—accelerated muscle-strength recovery, reduced soreness, and improved sleep via melatonin—come overwhelmingly from tart cherry (Prunus cerasus), so they should not be assumed identical for sweet cherry. Most studies are small, short, and use concentrated juice or powder rather than whole fresh fruit, limiting how far results generalize to ordinary dietary servings. Overall the human evidence is best described as moderate and mechanistically plausible but heterogeneous, with sweet-cherry-specific clinical data still sparse. As a whole food, sweet cherries are a sensible, nutrient-dense choice regardless of the targeted-effect uncertainty.

What is the typical dose of Sweet Cherry?

1 cup pitted (about 138 g, ~21 cherries) fresh; many trials use 200-300 mL cherry juice/drink once or twice daily

Is Sweet Cherry safe? Any cautions or side effects?

Generally safe as a food. High in fructose and sorbitol, so large amounts can cause bloating, gas, or diarrhea in sensitive people (including those with IBS or fructose malabsorption). Cherry pits/kernels contain amygdalin, which releases cyanide if crushed/chewed in quantity—do not eat the stones. People with latex-fruit or birch-pollen (oral allergy) syndrome may react. Concentrated cherry juice adds appreciable sugar and calories and may affect glycemic control if overconsumed. Theoretical additive effects with urate-lowering or anti-inflammatory regimens; patients on warfarin should keep vitamin K intake consistent (cherries are low but not zero).

How many studies support Sweet Cherry?

NutriDex cites 8 sources for Sweet Cherry, graded "Moderate".

Cite this page
APA

Peh, D. (2026). Sweet Cherry (Prunus avium): Benefits, Dosage, Side Effects & Evidence. NutriDex — The Supplement Research Compendium. Retrieved 26 Jun 2026, from https://nutridex.info/s/sweet-cherry

BibTeX
@misc{nutridex_sweet_cherry,
  author       = {Peh, Daryl},
  title        = {Sweet Cherry (Prunus avium): Benefits, Dosage, Side Effects \& Evidence},
  year         = {2026},
  howpublished = {NutriDex --- The Supplement Research Compendium},
  url          = {https://nutridex.info/s/sweet-cherry},
  note         = {Reviewed by Dr Daryl Peh, MBBS Singapore, MMed FM. Accessed 2026-06-26}
}

For medical claims, citing the underlying primary studies linked above is preferred. NutriDex is an educational reference, not medical advice.

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