NutriDex

The Supplement Research Compendium

🫐

Lychee

Litchi chinensis

Vitamin C-rich tropical fruit with polyphenol research

Preliminary evidence 🍎Fruits
Evidence tier
Preliminary
Research weight
Citations
11 verified / 11
Classification
Fruits
What the evidence says. Early or small human trials; promising but not yet conclusive.

Nutrition per serving 1 cup, ~9 lychees (100 g)

100gSERVING
  • Water 81.8 g82%
  • Sugars 15.2 g15%
  • Fibre 1.3 g1%
  • Other carbs 0 g0%
  • Protein 0.8 g1%
  • Fat 0.4 g0%
What's in one serving, by weight — average composition (USDA).
Vitamin C79%Copper16%Vitamin B66%Potassium4%Riboflavin5%Folate4%
One serving as % of the adult daily requirement (FDA Daily Values). The bold outer ring = 100% of a day's needs.
66 kcal0.83 g protein1.3 g fiber0.44 g fat
NutrientPer serving% daily value
Vitamin C72 mg79%
Copper0.15 mg16%
Vitamin B60.1 mg6%
Potassium171 mg4%
Riboflavin0.07 mg5%
Folate14 ug4%
Fiber1.3 g5%
Phosphorus31 mg2%
Magnesium10 mg2%

Composition data: USDA FoodData Central ↗

What is Lychee?

Lychee (Litchi chinensis) is a fruit used for high vitamin c contribution to antioxidant and immune support per serving. NutriDex grades the human evidence as Preliminary. Lychee is a sweet subtropical fruit that is an excellent source of vitamin C, providing roughly 80% of the Daily Value per ~100 g, alongside potassium, copper and flavanol-type polyphenols. The strongest human evidence comes not from the whole fruit but from Oligonol, a standardized lychee-derived oligomerized-polyphenol: randomized double-blind placebo-controlled trials report reduced abdominal visceral fat in overweight adults and improvements in liver fat fraction and gut microbiota composition in NAFLD patients, though one NAFLD RCT failed to beat placebo on its primary endpoint. These supplement doses are far more concentrated than what eating fresh fruit delivers, so the trial results should not be read as benefits of the fruit itself. Much of the remaining mechanistic and metabolic data (anti-inflammatory, anti-aging SIRT1/AMPK, renoprotective, anti-sarcopenia) comes from cell and rodent models. Large prospective cohorts show whole-fruit intake is associated with modestly lower type 2 diabetes risk, but lychee was not studied individually and fruit juice trends the opposite way. Overall, direct human evidence for fresh lychee is preliminary, with most benefit signals tied to extracts rather than the fruit as eaten.

Purported Benefits

High vitamin C contribution to antioxidant and immune support per serving
Lychee-derived polyphenol (Oligonol) reduced abdominal visceral fat in overweight adults in a randomized controlled trial
Litchi-derived polyphenol (Oligonol) improved liver fat (MRI-PDFF) and gut microbiota in a NAFLD trial
Source of potassium and copper supporting normal cardiovascular and metabolic function
Rich in flavanol/proanthocyanidin antioxidants studied for anti-inflammatory and metabolic effects
Whole-fruit consumption associated with modestly lower type 2 diabetes risk in large cohorts (lychee not studied individually)

Dosing & Compounds

Typical Dose
About 9 fresh lychees (~100 g edible flesh); Oligonol trials used 100-200 mg/day of standardized extract
Active Compounds
Vitamin C (L-ascorbic acid)Flavanol monomers (epicatechin, catechin)Proanthocyanidins / oligomerized flavanols (Oligonol)Anthocyanins (cyanidin-3-glucoside, mainly in pericarp)Phenolic acids (gallic, chlorogenic acid)Flavonols (rutin, quercetin glycosides)Potassium and copper (minerals)B vitamins (B6, folate, riboflavin)Seed-borne hypoglycins (hypoglycin A, MCPG) — toxic, not a benefit

Safety & Cautions

Generally safe as a food in normal amounts. The major documented hazard is consumption of unripe lychee (especially the seed and aril) on an empty stomach: the natural toxins hypoglycin A and methylenecyclopropylglycine (MCPG) inhibit fatty-acid oxidation/gluconeogenesis and have caused fatal hypoglycemic encephalopathy outbreaks in undernourished children (Muzaffarpur, India). Eat ripe fruit, in moderation, and never let children eat large quantities of unripe lychees while fasting; ensure an evening meal. High natural sugar content warrants moderation in diabetes and weight management. Lychee allergy and oral allergy syndrome are reported. Never eat the seed. Oligonol supplements are not equivalent to the fruit; discuss high-dose polyphenol supplements with a clinician if pregnant, on anticoagulants, or managing chronic disease. Educational only — always check with your doctor or pharmacist before combining Lychee with any medicine.

Key Studies ★ 11 studies

Systematic review and meta-analysis Lee 2025 ✓ Full text
Meta-analysis of 14 prospective cohorts: overall fruit juice showed no significant association with type 2 diabetes risk (RR 1.06), with subgroup signals favoring whole fruit over sweetened/non-100% juice.
Randomized controlled trial Takanari 2025 ✓ Full text
RCT (n=66 overweight adults; 63 analyzed): 200 mg/day Oligonol (lychee/tea flavanols) for 12 weeks significantly reduced abdominal visceral fat area on CT vs placebo, with no adverse events reported.
Randomized controlled trial Jinato 2022 ✓ Full text
RCT (n=38 NAFLD, 19/group): lychee-derived Oligonol for 24 weeks significantly reduced liver fat (MRI-PDFF) and shifted gut microbiota toward SCFA-producing bacteria, vs a non-significant change in placebo.
Randomized controlled trial Chayanupatkul 2022 ✓ Full text
RCT (n=40 NAFLD, 20/group): Oligonol did not significantly outperform placebo for >=30% MRI-PDFF reduction at 24 weeks (20% vs 15%, p=0.50); secondary metabolic outcomes similar between groups.
Prospective cohort analysis Muraki 2013 ✓ Full text
Pooled analysis of three US cohorts (~187,000 adults): every 3 weekly servings of whole fruit associated with HR 0.98 for type 2 diabetes, while fruit juice was associated with higher risk (HR 1.08). Lychee not assessed individually.
Case-control study Shrivastava 2017 ✓ Full text
Case-control study of 2014 Muzaffarpur outbreak: litchi consumption (matched OR 9.6) and absent evening meal linked to acute encephalopathy; arils contained hypoglycin A and MCPG; ~31% case fatality.
In vitro / animal study Park 2016 ✓ Full text
Mechanistic study: Oligonol from lychee upregulated SIRT1 and activated AMPK/autophagy pathways, extending lifespan in C. elegans and acting on aged-mouse splenocytes ex vivo.
Animal study Park 2015 ✓ Full text
Animal study (db/db diabetic mice): lychee-derived Oligonol (10-20 mg/kg/day, 8 weeks) attenuated NADPH-oxidase oxidative stress and advanced glycation end-products, reducing diabetic renal injury.
Animal study Chang 2019 ✓ Full text
Animal study (SAMP8 mice): dietary Oligonol increased skeletal muscle mass, fiber cross-sectional area and grip strength by enhancing protein synthesis and mitochondrial quality, alleviating sarcopenia.
In vitro / animal study Yum 2013 ✓ Full text
Animal study: oral Oligonol protected against DSS-induced colitis and azoxymethane/DSS colon adenoma formation in mice by suppressing NF-kB/STAT3, COX-2 and iNOS.
Animal study Kundu 2008 ✓ Full text
Animal study: Oligonol inhibited UVB-induced COX-2 expression and inflammatory signaling in hairless mouse skin via AP-1/C-EBP and p38 MAPK blockade.

Common questions about Lychee

What is Lychee used for?

Lychee is most often taken for High vitamin C contribution to antioxidant and immune support per serving, Lychee-derived polyphenol (Oligonol) reduced abdominal visceral fat in overweight adults in a randomized controlled trial, Litchi-derived polyphenol (Oligonol) improved liver fat (MRI-PDFF) and gut microbiota in a NAFLD trial, Source of potassium and copper supporting normal cardiovascular and metabolic function. Vitamin C-rich tropical fruit with polyphenol research

Does Lychee work — what does the evidence say?

Preliminary evidence. Early or small human trials; promising but not yet conclusive. Lychee is a sweet subtropical fruit that is an excellent source of vitamin C, providing roughly 80% of the Daily Value per ~100 g, alongside potassium, copper and flavanol-type polyphenols. The strongest human evidence comes not from the whole fruit but from Oligonol, a standardized lychee-derived oligomerized-polyphenol: randomized double-blind placebo-controlled trials report reduced abdominal visceral fat in overweight adults and improvements in liver fat fraction and gut microbiota composition in NAFLD patients, though one NAFLD RCT failed to beat placebo on its primary endpoint. These supplement doses are far more concentrated than what eating fresh fruit delivers, so the trial results should not be read as benefits of the fruit itself. Much of the remaining mechanistic and metabolic data (anti-inflammatory, anti-aging SIRT1/AMPK, renoprotective, anti-sarcopenia) comes from cell and rodent models. Large prospective cohorts show whole-fruit intake is associated with modestly lower type 2 diabetes risk, but lychee was not studied individually and fruit juice trends the opposite way. Overall, direct human evidence for fresh lychee is preliminary, with most benefit signals tied to extracts rather than the fruit as eaten.

What is the typical dose of Lychee?

About 9 fresh lychees (~100 g edible flesh); Oligonol trials used 100-200 mg/day of standardized extract

Is Lychee safe? Any cautions or side effects?

Generally safe as a food in normal amounts. The major documented hazard is consumption of unripe lychee (especially the seed and aril) on an empty stomach: the natural toxins hypoglycin A and methylenecyclopropylglycine (MCPG) inhibit fatty-acid oxidation/gluconeogenesis and have caused fatal hypoglycemic encephalopathy outbreaks in undernourished children (Muzaffarpur, India). Eat ripe fruit, in moderation, and never let children eat large quantities of unripe lychees while fasting; ensure an evening meal. High natural sugar content warrants moderation in diabetes and weight management. Lychee allergy and oral allergy syndrome are reported. Never eat the seed. Oligonol supplements are not equivalent to the fruit; discuss high-dose polyphenol supplements with a clinician if pregnant, on anticoagulants, or managing chronic disease.

How many studies support Lychee?

NutriDex cites 11 sources for Lychee, graded "Preliminary".

Cite this page
APA

Peh, D. (2026). Lychee (Litchi chinensis): Benefits, Dosage, Side Effects & Evidence. NutriDex — The Supplement Research Compendium. Retrieved 26 Jun 2026, from https://nutridex.info/s/lychee

BibTeX
@misc{nutridex_lychee,
  author       = {Peh, Daryl},
  title        = {Lychee (Litchi chinensis): Benefits, Dosage, Side Effects \& Evidence},
  year         = {2026},
  howpublished = {NutriDex --- The Supplement Research Compendium},
  url          = {https://nutridex.info/s/lychee},
  note         = {Reviewed by Dr Daryl Peh, MBBS Singapore, MMed FM. Accessed 2026-06-26}
}

For medical claims, citing the underlying primary studies linked above is preferred. NutriDex is an educational reference, not medical advice.

← Back to the full dex · All substances