NutriDex

The Supplement Research Compendium

By goal

Evidence-Backed Supplements for Exercise Recovery & Soreness

Hard training leaves muscles sore, fatigued and slow to bounce back, so many people reach for supplements to recover faster and blunt the next-day stiffness known as delayed-onset muscle soreness. The evidence here is genuinely tiered. Creatine monohydrate is the standout, with deep trial support for strength, power and training adaptation, while beta-alanine reliably buffers muscle acid in high-intensity work and omega-3 fatty acids have solid backing for their anti-inflammatory role. A middle tier is more mixed: tart cherry has reasonable data for soreness and sleep, and L-citrulline, ashwagandha and magnesium show moderate but variable support. Others sit on thinner ground for recovery specifically. Pomegranate, sweet cherry, Bacillus coagulans, pineapple (bromelain) and urolithin A are early-stage or studied mainly for unrelated outcomes, so claims should stay cautious. Responses vary widely between individuals and training styles. This page is educational, not medical advice; talk to your doctor or pharmacist before starting any supplement.

Best-supported here: Beta-Alanine (Strong), Creatine Monohydrate (Strong), Omega-3 (EPA/DHA) (Strong), Ashwagandha (Moderate) — each graded below by the weight of human evidence.
SupplementEvidence for this goalTypical doseKey cautionStudies
Beta-Alanine Strong for this goal 3.2–6.4 g/day, split to limit tingling; benefits build over 2–4 weeks. Safe. 19
Creatine Monohydrate Strong 3–5 g/day. Optional loading: 20 g/day (split) for 5–7 days. Very safe. 19
Omega-3 (EPA/DHA) Strong 1–2 g combined EPA+DHA/day; up to 4 g (Rx) for high triglycerides. Safe at typical doses. 20
Ashwagandha Moderate 300–600 mg/day of root extract (standardized to 5% withanolides), often… Avoid in pregnancy (traditionally abortifacient) and while breastfeeding. 18
Magnesium Moderate 200–400 mg elemental/day. Glycinate & citrate absorb best; oxide is poo… Safe. 20
Pomegranate Moderate A common serving is about 1 cup of arils (174 g) or roughly half a frui… Generally safe as a food. 8
Sweet Cherry Moderate 1 cup pitted (about 138 g, ~21 cherries) fresh; many trials use 200-300… Generally safe as a food. 8
Tart Cherry Moderate Common food serving is about 1 cup (155 g) of fresh pitted sour cherrie… Generally safe as a food. 10
Bacillus coagulans Preliminary for this goal For IBS: ~2 billion CFU/day of Unique IS-2 or 1 billion CFU/day of GBI-… Generally very well tolerated in trials with no serious adverse events and adverse-event ra… 8
Pineapple Preliminary A typical serving is 1 cup of fresh chunks (~165 g), delivering most of… Bromelain can cause oral tingling/irritation and mild GI upset (nausea, diarrhoea); IgE-med… 10
Urolithin A Preliminary for this goal 500–1000 mg once daily of standardized urolithin A (e.g., Mitopure), ta… Urolithin A has a favorable short-term safety profile in trials up to about 4 months at 250… 10
L-Citrulline Mixed for this goal 6–8 g citrulline malate (or ~3–4 g pure L-citrulline) ~60 min pre-exerc… Very safe, well tolerated. 22

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