Sorbitol has no credible link to cancer or systemic toxicity at dietary levels; the dominant, well-characterized effect is osmotic gastrointestinal intolerance. Because it is absorbed slowly and incompletely, unabsorbed sorbitol draws water into the bowel and is fermented by colonic bacteria, causing dose-dependent gas, bloating, cramping, and diarrhea. The landmark breath-hydrogen study (Hyams, Gastroenterology 1983) showed malabsorption in most healthy adults after as little as 5 g, mild symptoms around 10 g, and cramps/diarrhea around 20 g; reported laxation thresholds are roughly 0.17 g/kg in men and 0.24 g/kg in women. Young children are more susceptible (diarrhea reported after ~7.5 g), and people with IBS, fructose malabsorption, or SIBO are more sensitive — sorbitol is a FODMAP and is restricted on low-FODMAP diets. It is otherwise safe for people with diabetes and is non-cariogenic; the main practical caution is overconsumption of sugar-free products. EFSA's 2024 request for further genotoxicity data is a routine completeness step in re-evaluation, not a safety alert. Educational only — always check with your doctor or pharmacist before combining Sorbitol with any medicine.