NutriDex

The Supplement Research Compendium

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Rambutan

Nephelium lappaceum

Hairy tropical fruit with modest vitamin C and polyphenol-rich peel

Preliminary evidence 🍎Fruits
Evidence tier
Preliminary
Research weight
Citations
9 verified / 9
Classification
Fruits
What the evidence says. Early or small human trials; promising but not yet conclusive.

Nutrition per serving 5 fruit (100 g)

100gSERVING
  • Water 78 g78%
  • Sugars 20 g20%
  • Fibre 0.9 g1%
  • Protein 0.7 g1%
  • Fat 0.2 g0%
What's in one serving, by weight — average composition (USDA).
Vitamin C5%Copper7%Manganese15%Fiber3%Iron2%Potassium1%
One serving as % of the adult daily requirement (FDA Daily Values). The bold outer ring = 100% of a day's needs.
82 kcal0.65 g protein0.9 g fiber0.21 g fat
NutrientPer serving% daily value
Vitamin C4.9 mg5%
Copper0.07 mg7%
Manganese0.34 mg15%
Fiber0.9 g3%
Iron0.35 mg2%
Potassium42 mg1%
Calcium22 mg2%
Phosphorus9 mg1%

Composition data: USDA FoodData Central ↗

What is Rambutan?

Rambutan (Nephelium lappaceum) is a fruit used for modest vitamin c contribution supporting collagen synthesis and normal immune function. NutriDex grades the human evidence as Preliminary. Rambutan flesh is a low-fat tropical fruit whose best-documented nutritional role is as a modest source of vitamin C, fiber, copper and manganese. The great majority of its purported health effects (antioxidant, antidiabetic, antimicrobial, antiviral, anti-aging) come from polyphenol-rich peel and seed extracts studied in vitro and in rodent models, not from eating the fruit. For example, rambutan peel phenolic extract lowered fasting glucose, cholesterol and triglycerides in streptozotocin/high-fat-diet diabetic mice, and geraniin isolated from the rind inhibited dengue virus type-2 (IC about 1.75 microM) in Vero cell culture. There are essentially no randomized controlled trials or prospective cohorts evaluating rambutan fruit consumption and human disease outcomes, so causal claims for humans are unsupported. The concentrations of bioactives used in lab studies far exceed what edible flesh delivers, and peel/seed are not customary foods. Note also that the only USDA reference value for rambutan is for the fruit canned in syrup, which is substantially higher in sugar than fresh flesh. Overall the human weight of evidence is preliminary: rambutan is a healthful, vitamin-C-containing fruit, but specific therapeutic benefits remain unproven in people.

Purported Benefits

Modest vitamin C contribution supporting collagen synthesis and normal immune function
Antioxidant capacity from peel/seed polyphenols (geraniin, ellagitannins) demonstrated in vitro and in animal models
Antidiabetic / glycemic-lowering signals from peel phenolic extracts in diabetic rodents (not from eating the flesh)
Antimicrobial activity of peel extracts against foodborne and Gram-negative bacteria in vitro
Antiviral activity of geraniin from the rind against dengue virus type-2 in cell culture
Provides small amounts of dietary fiber, copper and manganese

Dosing & Compounds

Typical Dose
About 5-6 fresh fruit (~100 g edible flesh); flesh eaten raw, seed and peel not normally consumed.
Active Compounds
Hydrolyzable tannins / ellagitannins (geraniin, corilagin)Phenolic acids (ellagic acid, gallic acid)Flavonoids (quercetin, rutin, kaempferol glycosides)Vitamin C (L-ascorbic acid)Proanthocyanidins / condensed tanninsMinerals (potassium, copper, manganese, iron)Dietary fiber (soluble and insoluble)Seed lipids (oleic and arachidic acid in seed fat)

Safety & Cautions

Generally safe as food. The seed is reported to be mildly toxic when raw (contains saponin-like and possibly other antinutrient compounds) and should not be eaten unroasted. Peel and seed extracts used in research are not validated as supplements and lack human safety data. Canned rambutan is packed in sugar syrup; people with diabetes should account for the added carbohydrate. Allergy is uncommon but possible. No well-characterized drug interactions for the flesh, though concentrated polyphenol extracts could theoretically affect glucose-lowering or anticoagulant therapy. Educational only — always check with your doctor or pharmacist before combining Rambutan with any medicine.

Key Studies

Narrative review Afzaal 2023 ✓ Full text
Updated review documenting antioxidant, antimicrobial, anticancer, antidiabetic, antiobesity and antihypercholesterolemic activities across rambutan pulp, peel and seed; notes the peel and seed are richer in bioactives and that evidence is largely preclinical and by-product-focused.
Narrative review Tsong 2021 ✓ Full text
Review of Nephelium lappaceum and N. ramboutan-ake (pulasan) concluding their phenolics confer antioxidant and biological activities, with peel and seeds richer in bioactives than the edible flesh.
Narrative review Peixoto Araujo 2021 ✓ Full text
Review of functional and nutritional properties of selected Amazonian fruits covering rambutan, identifying geraniin and corilagin as principal bioactives with antioxidant and antimicrobial activity shown mainly in vitro and in animal assays.
In vitro digestion / Caco-2 study Tan 2023 ✓ Full text
During simulated gastrointestinal digestion, Caco-2 transport and colonic fermentation, rambutan peel polyphenols were transformed (e.g. geraniin to corilagin, ellagic and gallic acid) with changes in bioavailability and antioxidant capacity.
In vitro study Phuong 2020 ✓ Full text
Rambutan peel extracts showed antimicrobial activity against foodborne and Gram-negative bacteria in vitro, supporting their potential as natural food preservatives.
In vitro (human cells) Lee 2020 ✓ Full text
Flavonoid (kaempferol-type) compounds isolated from rambutan seeds showed senomorphic activity in aged human dermal fibroblasts, lowering senescence-marker expression and raising the longevity modulator SIRT1.
Animal study (mice) Ma 2017 ✓ Full text
Rambutan peel phenolic extract dose-dependently reduced fasting blood glucose, total cholesterol, triglycerides and glycated serum protein and restored hepatic glycogen in streptozotocin/high-fat-diet type-2 diabetic mice.
In vitro + animal study Zhuang 2017 ✓ Full text
Rambutan peel phenolics (total phenolics 877 mg GAE/g; geraniin highest at 122 mg/g) protected H2O2-stressed HepG2 cells and reduced D-galactose-induced liver and kidney damage in aging mice.
In vitro / molecular study Abdul Ahmad 2017 ✓ Full text
Geraniin isolated from rambutan rind inhibited dengue virus type-2 (IC ~1.75 microM) by binding the viral envelope E-DIII protein and blocking early viral attachment in Vero cells.

Common questions about Rambutan

What is Rambutan used for?

Rambutan is most often taken for Modest vitamin C contribution supporting collagen synthesis and normal immune function, Antioxidant capacity from peel/seed polyphenols (geraniin, ellagitannins) demonstrated in vitro and in animal models, Antidiabetic / glycemic-lowering signals from peel phenolic extracts in diabetic rodents (not from eating the flesh), Antimicrobial activity of peel extracts against foodborne and Gram-negative bacteria in vitro. Hairy tropical fruit with modest vitamin C and polyphenol-rich peel

Does Rambutan work — what does the evidence say?

Preliminary evidence. Early or small human trials; promising but not yet conclusive. Rambutan flesh is a low-fat tropical fruit whose best-documented nutritional role is as a modest source of vitamin C, fiber, copper and manganese. The great majority of its purported health effects (antioxidant, antidiabetic, antimicrobial, antiviral, anti-aging) come from polyphenol-rich peel and seed extracts studied in vitro and in rodent models, not from eating the fruit. For example, rambutan peel phenolic extract lowered fasting glucose, cholesterol and triglycerides in streptozotocin/high-fat-diet diabetic mice, and geraniin isolated from the rind inhibited dengue virus type-2 (IC about 1.75 microM) in Vero cell culture. There are essentially no randomized controlled trials or prospective cohorts evaluating rambutan fruit consumption and human disease outcomes, so causal claims for humans are unsupported. The concentrations of bioactives used in lab studies far exceed what edible flesh delivers, and peel/seed are not customary foods. Note also that the only USDA reference value for rambutan is for the fruit canned in syrup, which is substantially higher in sugar than fresh flesh. Overall the human weight of evidence is preliminary: rambutan is a healthful, vitamin-C-containing fruit, but specific therapeutic benefits remain unproven in people.

What is the typical dose of Rambutan?

About 5-6 fresh fruit (~100 g edible flesh); flesh eaten raw, seed and peel not normally consumed.

Is Rambutan safe? Any cautions or side effects?

Generally safe as food. The seed is reported to be mildly toxic when raw (contains saponin-like and possibly other antinutrient compounds) and should not be eaten unroasted. Peel and seed extracts used in research are not validated as supplements and lack human safety data. Canned rambutan is packed in sugar syrup; people with diabetes should account for the added carbohydrate. Allergy is uncommon but possible. No well-characterized drug interactions for the flesh, though concentrated polyphenol extracts could theoretically affect glucose-lowering or anticoagulant therapy.

How many studies support Rambutan?

NutriDex cites 9 sources for Rambutan, graded "Preliminary".

Cite this page
APA

Peh, D. (2026). Rambutan (Nephelium lappaceum): Benefits, Dosage, Side Effects & Evidence. NutriDex — The Supplement Research Compendium. Retrieved 26 Jun 2026, from https://nutridex.info/s/rambutan

BibTeX
@misc{nutridex_rambutan,
  author       = {Peh, Daryl},
  title        = {Rambutan (Nephelium lappaceum): Benefits, Dosage, Side Effects \& Evidence},
  year         = {2026},
  howpublished = {NutriDex --- The Supplement Research Compendium},
  url          = {https://nutridex.info/s/rambutan},
  note         = {Reviewed by Dr Daryl Peh, MBBS Singapore, MMed FM. Accessed 2026-06-26}
}

For medical claims, citing the underlying primary studies linked above is preferred. NutriDex is an educational reference, not medical advice.

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